MORN3

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Description

The MORN3 (MORN repeat containing 3) is a protein-coding gene located on chromosome 12.

MORN3 forms a complex called the 'suppresome' by bringing together SIRT1 and MDM2. This complex regulates modifications to p53, a tumor suppressor protein. SIRT1 removes acetyl groups from p53, inactivating it, while MDM2 adds ubiquitin tags, marking it for degradation. Both actions promote cell survival and proliferation. MORN3 may also play a role in regulating spermatogenesis.

MORN3 is also known as -.

Associated Diseases

• primary familial polycythemia due to EPO receptor mutation
• alpha thalassemia-intellectual disability syndrome type 1
• erythrocytosis, familial, 6
• erythrocytosis, familial, 3
• hemolytic anemia due to diphosphoglycerate mutase deficiency
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• erythrocytosis, familial, 4
• delta-beta-thalassemia
• thrombocythemia 2
• familial isolated congenital asplenia
• hemolytic anemia due to erythrocyte adenosine deaminase overproduction
• elliptocytosis 2
• Rh deficiency syndrome
• cryohydrocytosis
• overhydrated hereditary stomatocytosis
• dehydrated hereditary stomatocytosis