MORF4L2

Description

The MORF4L2 (mortality factor 4 like 2) is a protein-coding gene located on chromosome X.

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.

MORF4L2 is a component of the NuA4 histone acetyltransferase complex, which plays a key role in activating transcription of specific genes. NuA4 achieves this by acetylating nucleosomal histones H4 and H2A, altering nucleosome-DNA interactions and promoting interactions with other transcription-regulating proteins. NuA4 is essential for various transcriptional programs, including those related to oncogene and proto-oncogene-mediated growth induction, tumor suppressor-mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The ATPase and helicase activities of the NuA4 complex are partly attributed to the association of RUVBL1 and RUVBL2 with EP400. NuA4 can directly participate in DNA repair by being recruited to damaged DNA sites. Additionally, MORF4L2 is a component of the MSIN3A complex, which represses transcription by deacetylating nucleosomal histones.

MORF4L2 is also known as MORFL2, MRGX.

Associated Diseases

WES Whole Exome Sequencing