MORF4L1
Description
The MORF4L1 (mortality factor 4 like 1) is a protein-coding gene located on chromosome 15.
Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.
== Interactions == MORF4L1 has been shown to interact with MYST1, Retinoblastoma protein and MRFAP1.
MORF4L1 is a component of the NuA4 histone acetyltransferase (HAT) complex, which plays a crucial role in the transcriptional activation of specific genes. The complex achieves this by acetylating nucleosomal histones H4 and H2A, thereby altering nucleosome-DNA interactions and facilitating interactions with other proteins that positively regulate transcription. NuA4 is essential for activating transcriptional programs associated with oncogene and proto-oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair. The complex's ATPase and helicase activities are contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 also directly participates in DNA repair by being recruited to sites of DNA damage. As a component of the SIN3B complex, MORF4L1 represses transcription and counteracts the histone acetyltransferase activity of EP300 by recognizing H3K27ac marks through PHF12 and the action of the histone deacetylase HDAC2. The SIN3B complex is recruited downstream of constitutively active gene transcriptional start sites, where it interacts with histones and moderates histone acetylation and RNA polymerase II progression within transcribed regions, thereby contributing to transcriptional regulation. MORF4L1 is essential for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). It is involved in localizing PALB2, BRCA2, and RAD51 (but not BRCA1) to DNA-damage foci.
MORF4L1 is also known as Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6.
