MORC1

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Description

The MORC1 (MORC family CW-type zinc finger 1) is a protein-coding gene located on chromosome 3.

MORC1 plays a crucial role in spermatogenesis, contributing to the process of sperm cell development. It is essential for establishing new DNA methylation patterns and silencing transposable elements, which are DNA sequences capable of moving within the genome. This silencing is critical in male embryonic germ cells to ensure the stability and integrity of the developing germline.

MORC1 is also known as CT33, MORC, ZCW6.

Associated Diseases

• substance abuse
• partial chromosome Y deletion
• male infertility with teratozoospermia due to single gene mutation
• spermatogenic failures 50
• spermatogenic failure 25
• spermatogenic failure, X-linked, 2
• isochromosomy Yp
• spermatogenic failure 61
• spermatogenic failure 73
• spermatogenic failure 74
• spermatogenic failure 48
• spermatogenic failure 63
• congenital bilateral absence of vas deferens
• spermatogenic failure 22
• isochromosomy Yq
• spinocerebellar ataxia type 32
• spermatogenic failure 52