MOB1B
Description
The MOB1B (MOB kinase activator 1B) is a protein-coding gene located on chromosome 4.
MOB1B, also known as Mob1 homolog 1A, is a protein encoded by the MOBKL1A gene in humans. It is similar to the yeast Mob1 protein, which binds Mps1p, a protein kinase crucial for spindle pole body duplication and mitotic checkpoint regulation. MOB1B is involved in the Hippo signaling pathway.
MOB1B acts as an activator of LATS1/2 within the Hippo signaling pathway. This pathway is critical for regulating organ size and suppressing tumor growth by limiting cell proliferation and promoting apoptosis. The core of this pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 (in complex with MOB1). LATS1/2 then phosphorylates and inactivates YAP1 and WWTR1/TAZ, preventing YAP1 from entering the nucleus to regulate genes associated with cell proliferation, death, and migration. MOB1B also stimulates the kinase activity of STK38L.
MOB1B is also known as MATS2, MOB4A, MOBKL1A.
