MOB1A
Description
The MOB1A (MOB kinase activator 1A) is a protein-coding gene located on chromosome 2.
MOB kinase activator 1A is an enzyme that in humans is encoded by the MOB1A gene.
MOB1A activates LATS1/2, key kinases in the Hippo signaling pathway, which controls organ size and suppresses tumors by limiting cell growth and promoting programmed cell death (apoptosis). This pathway involves a cascade of kinases where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 in complex with MOB1. LATS1/2 then phosphorylates and deactivates YAP1 oncoprotein and WWTR1/TAZ, inhibiting their nuclear translocation. This prevents them from regulating genes involved in cell proliferation, death, and movement. MOB1A also stimulates the activity of STK38 and STK38L kinases, working together with STK3/MST2 to activate STK38. It interacts directly with STK38, STK38L, LATS1, and LATS2, forming a complex with STK38 and STK3/MST2.
MOB1A is also known as C2orf6, MABKL1B, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B.
Associated Diseases
- Brugada syndrome
- familial atrial fibrillation
- long QT syndrome 11
- Brugada syndrome 9
- long QT syndrome 14
- Jervell and Lange-Nielsen syndrome 1
- long QT syndrome 1
- long QT syndrome 10
- long QT syndrome 9
- atrial fibrillation, familial, 9
- Brugada syndrome 3
- long QT syndrome 12
- sick sinus syndrome 1
- atrial fibrillation, familial, 3
- familial sick sinus syndrome
- long QT syndrome 5
- long QT syndrome 13
- Jervell and Lange-Nielsen syndrome 2
