MOAP1

Description

The MOAP1 (modulator of apoptosis 1) is a protein-coding gene located on chromosome 14.

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene. The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.

MOAP1 is a retrotransposon-derived protein that forms virion-like capsids. It acts as an effector of BAX during apoptosis, localizing to the outer mitochondrial membrane and associating with BAX upon apoptosis induction. This association facilitates BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. MOAP1 is crucial for death receptor-dependent apoptosis. When bound to RASSF1, it promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Furthermore, MOAP1 promotes autophagy by facilitating phagophore closure through interaction with ATG8 proteins. It also acts as an inhibitor of the NFE2L2/NRF2 pathway by interacting with SQSTM1, promoting dissociation of SQSTM1 inclusion bodies that sequester KEAP1, thereby relieving inactivation of the BCR(KEAP1) complex.

MOAP1 is also known as MAP-1, PNMA4.

Associated Diseases

WES Whole Exome Sequencing