MNDA
Description
The MNDA (myeloid cell nuclear differentiation antigen) is a protein-coding gene located on chromosome 1.
Myeloid cell Nuclear Differentiation Antigen (MNDA) is a protein encoded by the MNDA gene in humans. It is exclusively found in the nuclei of granulocyte and monocyte cells. A significant portion of MNDA shares similarity with a family of interferon-inducible mouse genes, suggesting a role in interferon response. MNDA's expression is significantly increased in human monocytes exposed to interferon alpha. It is located near other genes like FCER1A, APCS, CRP, and SPTA1. MNDA's expression pattern and regulation resemble IFI16, indicating their involvement in blood cell-specific responses to interferons.
MNDA, a protein primarily found in the nuclei of granulocyte and monocyte cells, acts as a transcriptional activator or repressor within the myeloid lineage. It plays a crucial role in the granulocyte and monocyte cells' response to interferon. Interestingly, MNDA enhances the binding of the transcriptional repressor protein YY1 to DNA.
MNDA is also known as PYHIN3.
Associated Diseases
- type 1 diabetes mellitus
- retinitis pigmentosa and erythrocytic microcytosis
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- X-linked sideroblastic anemia 1
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- beta-thalassemia-X-linked thrombocytopenia syndrome
- thrombocytopenia 7
