MMS22L
Description
The MMS22L (MMS22 like, DNA repair protein) is a protein-coding gene located on chromosome 6.
Methyl methanesulfonate-sensitivity protein 22-like, also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L gene.
The MMS22L-TONSL complex is involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. It plays a crucial role in maintaining genome integrity during DNA replication by promoting the assembly of RAD51 filaments on single-stranded DNA (ssDNA). The complex is recruited to DSBs after histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A). Following recruitment, it promotes the recruitment of RAD51 filaments and subsequent homologous recombination. MMS22L contributes to this process by binding ssDNA.
MMS22L is also known as C6orf167, dJ39B17.2.
