MMP28
Description
The MMP28 (matrix metallopeptidase 28) is a protein-coding gene located on chromosome 17.
MMP-28, also known as epilysin, is an enzyme encoded by the MMP28 gene in humans. It belongs to the matrix metalloproteinase family, which are involved in tissue regulation. MMPs are known for degrading the extracellular matrix, regulating cell surface receptors, and releasing growth factors and adhesion molecules to modulate inflammation. MMP-28 is unique in that it is found in many regular tissues, suggesting a role in maintaining the healthy structure and function of most tissues. MMPs often regulate their expression through feedback loops, responding to and releasing growth hormones. MMP-28 is less common in tissues like the brain, colon, heart, and lungs, but it is highly expressed in organs such as the testes. Epilysin is also found in high concentrations in basal keratinocytes of injured skin, even at a distance from the wound, indicating a role in tissue repair. MMP-28 can alter the cell membrane to become more adhesive, preventing cell migration. MMP-28 is a 520 amino acid long protein.
MMP28 is also known as EPILYSIN, MM28, MMP-25, MMP-28, MMP25.
Associated Diseases
- pachyonychia congenita
- urinary bladder carcinoma
- isolated agammaglobulinemia
- cancer
- common variable immunodeficiency
- hyper-IgM syndrome type 2
- immunodeficiency, common variable, 4
- hyper-IgM syndrome type 3
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- neutropenia, severe congenital, 1, autosomal dominant
- hyper-IgM syndrome type 5
