MMP19
Description
The MMP19 (matrix metallopeptidase 19) is a protein-coding gene located on chromosome 12.
MMP-19, also known as Matrix metalloproteinase RASI, is an enzyme encoded by the MMP19 gene in humans. MMPs are a family of proteins involved in breaking down the extracellular matrix, a crucial process in various biological events such as embryonic development, reproduction, tissue repair, and disease processes like arthritis and cancer spread. Most MMPs are initially inactive and require activation by other enzymes. MMP-19 is expressed in human skin and blood vessel cells, contributing to cell growth, movement, blood vessel formation, and cell attachment. Different versions of the MMP19 gene have been identified, producing various forms of the MMP-19 protein.
MMP-19 is an endopeptidase that breaks down various components of the extracellular matrix, including aggrecan and cartilage oligomeric matrix protein (COMP), during developmental processes, blood clotting, and disease conditions such as arthritis. It is also implicated in the formation of new blood vessels (angiogenesis). MMP-19 specifically hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
MMP19 is also known as CODA, MMP18, RASI-1.
