MMP17
Description
The MMP17 (matrix metallopeptidase 17) is a protein-coding gene located on chromosome 12.
MMP17, also known as MT-MMP 4, is an enzyme involved in the breakdown of the extracellular matrix. It belongs to the membrane-type MMP (MT-MMP) subfamily, and unlike most MMPs, it is GPI-anchored to the cell membrane instead of being secreted. MMP17 is responsible for activating MMP2, another important enzyme involved in matrix breakdown.
MMP17 is also known as MMP-17, MT4-MMP, MT4MMP, MTMMP4.
Associated Diseases
- nephronophthisis
- Senior-Loken syndrome
- nephronophthisis 1
- nephronophthisis 3
- Ochoa syndrome
- Senior-Loken syndrome 1
- renal hypoplasia
- nephronophthisis 11
- acquired central diabetes insipidus
- adenine phosphoribosyltransferase deficiency
- congenital hydronephrosis
