MMP12
Description
The MMP12 (matrix metallopeptidase 12) is a protein-coding gene located on chromosome 11.
MMP12, also known as macrophage metalloelastase (MME) or macrophage elastase (ME), is an enzyme encoded by the MMP12 gene in humans. It belongs to the matrix metalloproteinase (MMP) family, which plays a crucial role in breaking down the extracellular matrix during normal physiological processes like embryonic development, reproduction, and tissue remodeling. MMPs are secreted as inactive proproteins, requiring activation by extracellular proteinases. The active enzyme consists of two domains: the catalytic domain responsible for enzymatic activity and the hemopexin-like domain involved in substrate recognition. MMP12 is thought to be cleaved at both ends to produce the active enzyme. It primarily degrades soluble and insoluble elastin. The MMP12 gene is located on chromosome 11q22.3. MMP12 may contribute to aneurysm formation and has been implicated in emphysema development in both mice and humans.
MMP12 is also known as HME, ME, MME, MMP-12.
