MMP11
Description
The MMP11 (matrix metallopeptidase 11) is a protein-coding gene located on chromosome 22.
Stromelysin-3 (SL-3), also known as matrix metalloproteinase-11 (MMP-11), is an enzyme that in humans is encoded by the MMP11 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
MMP11, also known as Stromelysin-3, is implicated in the advancement of epithelial cancers.
MMP11 is also known as SL-3, ST3, STMY3.
