MLLT6
Description
The MLLT6 gene (also known as AF6) plays a crucial role in cellular development and growth. It encodes a protein that interacts with other proteins involved in gene expression, particularly in the context of leukemia and other cancers. MLLT6 is often disrupted by chromosomal rearrangements, leading to the formation of fusion proteins that drive uncontrolled cell proliferation.
Associated Diseases
- Acute Myeloid Leukemia (AML)
- Acute Lymphoblastic Leukemia (ALL)
- Chronic Myeloid Leukemia (CML)
- Myelodysplastic Syndromes (MDS)
- Solid Tumors (e.g., breast cancer, lung cancer)
- Neuroblastoma
Did you know?
MLLT6 was initially identified as a fusion partner of the MLL gene, a common event in leukemia. This discovery highlighted the critical role of MLLT6 in leukemogenesis.
