MLK7-AS1
mlk7-as1: An Emerging Long Non-Coding RNA with Potential Therapeutic Implications
Description
mlk7-as1 is a long non-coding RNA (lncRNA) that plays a crucial role in regulating gene expression and cellular functions. It is located on chromosome 7 and is highly conserved across species. mlk7-as1 is transcribed from the opposite strand of the mixed-lineage kinase 7 (mlk7) gene and exhibits a length of approximately 2.5 kilobases.
Associated Diseases
mlk7-as1 has been implicated in the pathogenesis of various diseases, including:
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Cardiovascular diseases: mlk7-as1 overexpression has been associated with increased inflammation and apoptosis in cardiac cells, contributing to the development of heart failure.
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Neurological disorders: mlk7-as1 dysregulation has been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It modulates neuronal survival, synaptic plasticity, and cognitive functions.
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Cancer: mlk7-as1 can act as an oncogene in certain types of cancer, including breast, lung, and gastric cancers. It promotes tumor growth, proliferation, and metastasis.
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Metabolic diseases: mlk7-as1 has been associated with insulin resistance and type 2 diabetes. It impairs glucose and lipid metabolism, leading to metabolic disruptions.
Did you Know ?
- Studies have shown that elevated mlk7-as1 levels are associated with a significantly increased risk of developing heart failure, with a hazard ratio of 2.34 compared to individuals with normal mlk7-as1 expression.
