MKNK2

Description

The MKNK2 (MAPK interacting serine/threonine kinase 2) is a protein-coding gene located on chromosome 19.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

== Interactions == MNK2 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma. MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.

MKNK2 is a serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1, and EIF4E. It may play a role in the response to environmental stress and cytokines. MKNK2 appears to regulate translation by phosphorylating EIF4E, increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. It is required for mediating PP2A-inhibition-induced EIF4E phosphorylation and triggers EIF4E shuttling from the cytoplasm to the nucleus. Isoform 1 displays a high basal kinase activity, while isoform 2 exhibits very low kinase activity. MKNK2 acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. It is a negative regulator for signals that control the generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. MKNK2 is involved in anti-apoptotic signaling in response to serum withdrawal.

MKNK2 is also known as GPRK7, MNK2.

Associated Diseases

WES Whole Exome Sequencing