MIS12
Description
The MIS12 (MIS12 kinetochore complex component) is a protein-coding gene located on chromosome 17.
The MIS12 gene encodes the MIS12 protein, which is involved in various cellular processes, including chromosome alignment, segregation, and kinetochore formation during mitosis. It interacts with several other proteins, including NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1, and CBX5.
The MIS12 complex plays a crucial role in ensuring proper chromosome alignment and segregation during mitosis. This complex is essential for kinetochore formation, which is the attachment point for microtubules that pull chromosomes apart during cell division. The MIS12 complex is also vital for the accurate attachment of microtubules to the kinetochore, ensuring proper chromosome segregation. These functions are critical for maintaining genomic stability and preventing aneuploidy.
MIS12 is also known as 2510025F08Rik, KNTC2AP, MTW1, hMis12.
