MIR6760
The Fascinating Role of mir6760 in Human Health and Disease
Description
The mir6760 gene is located on chromosome 12q13.13 and encodes a microRNA (miRNA) called miR-6760. MiRNAs are small, non-coding RNA molecules that play a crucial role in regulating gene expression. They bind to complementary sequences on messenger RNAs (mRNAs) and inhibit their translation or degradation.
Associated Diseases
Aberrant expression of miR-6760 has been implicated in the development and progression of various diseases, including:
- Cancer: miR-6760 has been found to be downregulated in various cancer types, such as breast cancer, prostate cancer, and lung cancer. Its reduced expression is associated with increased cell proliferation, invasion, and metastasis.
- Cardiovascular disease: miR-6760 has been shown to regulate the expression of genes involved in angiogenesis, heart development, and cardiac function. Dysregulation of miR-6760 has been linked to cardiovascular diseases such as coronary artery disease and heart failure.
- Neurological disorders: miR-6760 has been implicated in the pathogenesis of several neurological disorders, including Alzheimer‘s disease, Parkinson‘s disease, and schizophrenia. Alterations in miR-6760 expression have been associated with neuronal dysfunction, apoptosis, and neuroinflammation.
Did you Know ?
Studies have shown that in breast cancer patients, low levels of miR-6760 are associated with a significantly worse prognosis and reduced overall survival rates. In contrast, patients with high miR-6760 levels have better clinical outcomes.
