MIR499A
Mir499a Gene: A Comprehensive Guide
Description
The microRNA-499a (mir499a) gene is located on chromosome 20q13.12. It encodes a small non-coding RNA molecule that plays a crucial role in regulating gene expression. Mir499a is involved in various cellular processes, including development, differentiation, cell cycle regulation, and apoptosis.
Associated Diseases
Alterations in mir499a expression have been implicated in several human diseases, including:
- Cancer: Mir499a is frequently downregulated in various cancers, such as breast cancer, lung cancer, and colorectal cancer. Its reduced expression promotes tumor growth and metastasis.
- Neurodegenerative disorders: Mir499a has been linked to the development of neurodegenerative disorders like Alzheimer‘s disease and Parkinson‘s disease. Its dysregulation affects neuronal survival and function.
- Cardiovascular diseases: Mir499a is involved in the regulation of cardiac function and vascular remodeling. Its altered expression contributes to cardiovascular diseases such as heart failure and atherosclerosis.
Did you Know ?
Research has shown that approximately 50% of breast cancer patients exhibit decreased mir499a expression. This downregulation is associated with an increased risk of metastasis and poor prognosis.
