MINK1
Description
The MINK1 (misshapen like kinase 1) is a protein-coding gene located on chromosome 17.
Misshapen-like kinase 1 (MINK1) is an enzyme encoded by the MINK1 gene in humans. It is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. Structurally similar to kinases related to NIK, MINK1 may belong to a distinct subfamily within the GCK family. Studies in mice suggest an upregulation of MINK1 expression during postnatal cerebral development, activating the JNK and p38 pathways. Alternative splicing generates four transcript variants encoding distinct isoforms. MINK1 has been shown to interact with NCK1.
MINK1 acts as a negative regulator of Rap2-mediated signaling, influencing neuronal structure and AMPA receptor trafficking. It plays a vital role in maintaining normal synaptic density, dendrite complexity, and surface AMPA receptor expression in hippocampal neurons. MINK1 can activate the JNK and p38 pathways, mediating the stimulation of the stress-activated protein kinase p38 MAPK downstream of the Raf/ERK pathway. It phosphorylates TANC1 upon stimulation by RAP2A, MBP, and SMAD1. Additionally, MINK1 has a crucial role in negative selection of thymocytes, potentially by linking NCK1 to JNK1 activation.
MINK1 is also known as B55, MAP4K6, MEKKK 6, MINK, YSK2, ZC3.
Associated Diseases
- Alzheimer disease
- multiple sclerosis
- Parkinson disease
- lysosomal storage disease
- ovarian cancer
- endometrial cancer
- congenital myasthenic syndrome
- substance abuse
- esophageal cancer
