MID1 : midline 1
Description
The MID1 (midline 1) is a protein-coding gene located on chromosome X.
The MID1 gene belongs to the tripartite motif (TRIM) family, a group of genes involved in various cellular processes. TRIM proteins, including MID1, are key players in the cellular machinery responsible for recycling unwanted proteins through ubiquitination. MID1 encodes the midline-1 protein, which binds to microtubules, essential components of the cytoskeleton that maintain cell shape, facilitate cell division, and support cell migration. Midline-1 plays a crucial role in recycling specific proteins, including protein phosphatase 2A (PP2A), integrin alpha-4 (ITGA4), and serine/threonine-protein kinase 36 (STK36). The efficient recycling of these proteins is vital for normal cellular function.
MID1, as an E3 ubiquitin ligase, targets IGBP1, leading to its monoubiquitination. This action deprotects the catalytic subunit of protein phosphatase PP2A, making it susceptible to polyubiquitination and subsequent degradation.
MID1 is also known as BBBG1, FXY, GBBB, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY.
