Sutterella
Sutterella: An Emerging Pathogen in Human Disease
Description
Sutterella is a genus of Gram-negative, anaerobic bacteria that commonly reside in the human gastrointestinal tract. They are rod-shaped bacteria that are non-motile and have a lack of cytochrome oxidase. Sutterella species are known for their ability to ferment carbohydrates and produce short-chain fatty acids.
Associated Diseases
Sutterella species have been implicated in a growing number of human diseases, including:
- Inflammatory bowel disease (IBD): Sutterella species are commonly found in the stool of patients with IBD, particularly Crohn‘s disease. The bacteria may contribute to intestinal inflammation and tissue damage through the production of pro-inflammatory mediators.
- Colorectal cancer: Certain Sutterella species have been associated with an increased risk of colorectal cancer. The bacteria may alter the gut microbiome, leading to the accumulation of cancer-promoting metabolites.
- Periodontal disease: Sutterella species are also associated with periodontal disease, a chronic inflammatory condition of the gums and bone surrounding the teeth. The bacteria may contribute to the inflammation and tissue destruction seen in this disease.
- Sepsis: Sutterella species can occasionally cause sepsis, a life-threatening infection that spreads throughout the body. Sepsis caused by Sutterella is typically associated with gastrointestinal or abdominal infections.
Did you Know ?
- Sutterella species are found in the gastrointestinal tract of approximately 50-80% of healthy adults.
