Ruminococcus gnavus
Ruminococcus gnavus: An Emerging Player in Human Health and Disease
Description
Ruminococcus gnavus is a Gram-positive, anaerobic bacterium found in the human gut microbiome. It is the predominant species in the genus Ruminococcus and plays a crucial role in the digestion of dietary fiber.
Associated Diseases
- Inflammatory Bowel Disease (IBD): R. gnavus has been associated with an increased risk of developing Crohn‘s disease, a type of IBD. It is believed to produce toxins that damage the intestinal lining, leading to inflammation and ulceration.
- Colorectal Cancer: Studies have linked R. gnavus to an increased risk of colorectal cancer, particularly in individuals with a family history of the disease. It is thought to promote cancer development by producing enzymes that break down the protective mucus layer in the colon.
- Sepsis: R. gnavus has been identified as a potential pathogen in sepsis, a life-threatening condition characterized by the systemic inflammatory response to infection. It is believed to trigger the release of cytokines and inflammatory markers, leading to organ damage and tissue destruction.
Did you Know ?
A study published in the journal Nature Microbiology revealed that individuals with high levels of R. gnavus in their gut microbiome had a 3-fold increased risk of developing Crohn‘s disease compared to those with low levels.
