MICAL2
Description
The MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2) is a protein-coding gene located on chromosome 11.
Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene.
MICAL2 is a methionine monooxygenase that promotes depolymerization of F-actin by oxidizing residues 'Met-44' and 'Met-47' on actin, forming methionine-sulfoxide. This leads to actin filament disassembly and prevents repolymerization. MICAL2 also regulates the disassembly of branched actin networks by oxidizing ARP3B-containing ARP2/3 complexes, resulting in ARP3B dissociation from the network. MICAL2 acts as a key regulator of the SRF signaling pathway triggered by nerve growth factor and serum. It mediates oxidation and depolymerization of nuclear actin, increasing the presence of MKL1/MRTF-A in the nucleus, and promoting SRF:MKL1/MRTF-A-dependent gene transcription. Importantly, MICAL2 does not activate SRF:MKL1/MRTF-A through RhoA.
MICAL2 is also known as Ebitein1, MICAL-2, MICAL2PV1, MICAL2PV2, MICALCL, mical-cL.
