MIB1
Description
The MIB1 (MIB E3 ubiquitin protein ligase 1) is a protein-coding gene located on chromosome 18.
MIB1, encoded by the MIB1 gene in humans, is an E3 ubiquitin-protein ligase that plays a role in regulating apoptosis. An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1. This is distinct from MIB1, an enzyme with a different function.
MIB1 is an E3 ubiquitin ligase that mediates ubiquitination of Delta receptors, which are ligands of Notch proteins. It positively regulates Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB1 may also mediate ubiquitination and subsequent proteasomal degradation of DAPK1, antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. MIB1 is involved in ubiquitination of centriolar satellite proteins CEP131, CEP290 and PCM1, which inhibits primary cilium formation in proliferating cells. It mediates 'Lys-63'-linked polyubiquitination of TBK1, likely participating in kinase activation.
MIB1 is also known as DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6.
