MGST2
Description
The MGST2 (microsomal glutathione S-transferase 2) is a protein-coding gene located on chromosome 4.
MGST2 (Microsomal glutathione S-transferase 2) is a human enzyme encoded by the MGST2 gene. It belongs to the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family, which includes proteins involved in the production of inflammatory mediators like leukotrienes and prostaglandin E. MGST2 catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.
MGST2 catalyzes a variety of glutathione-dependent reactions, including the reduction of lipid hydroperoxides like 5-HPETE, the conjugation of xenobiotic electrophiles such as 1-chloro-2,4-dinitrobenzene (CDNB), and the formation of leukotriene C4 (LTC4) from leukotriene A4. MGST2 is also involved in oxidative DNA damage induced by ER stress and anticancer agents through the activation of LTC4 biosynthesis in nonimmune cells. (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457)
MGST2 is also known as GST2, MGST-II.
