MGLL
Description
The MGLL (monoglyceride lipase) is a protein-coding gene located on chromosome 3.
MGLL (Monoacylglycerol lipase) is an enzyme encoded by the MGLL gene in humans. It is a membrane-associated enzyme that belongs to the serine hydrolase superfamily. MGLL plays a crucial role in breaking down fats (glycerol monoesters of long-chain fatty acids) into fatty acids and glycerol. It works together with hormone-sensitive lipase (LIPE) to break down fat stores in cells. MGLL also helps with the breakdown of monoglycerides that come from lipoprotein triglycerides. One of MGLL's most important functions is breaking down the endocannabinoid 2-arachidonoylglycerol (2-AG), which is a signaling molecule in the brain. This helps regulate the endocannabinoid system, which is involved in many functions like mood, appetite, and pain. Inhibitors of MGLL, such as URB-602, URB-754, and JZL-184, can produce effects similar to cannabinoids in mice.
MGLL converts monoacylglycerides to free fatty acids and glycerol. It hydrolyzes the endocannabinoid 2-arachidonoylglycerol, which plays a role in regulating endocannabinoid signaling, pain perception, and nociperception. MGLL also regulates levels of fatty acids that act as signaling molecules and promote cancer cell migration, invasion, and tumor growth.
MGLL is also known as HU-K5, HUK5, MAGL, MGL.
Associated Diseases
- cancer
- gastrointestinal stromal tumor
- tic disorder
- type 2 diabetes mellitus
- microphthalmia with limb anomalies
