MGAT4B

Description

The MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B) is a protein-coding gene located on chromosome 5.

MGAT4B gene encodes a key glycosyltransferase involved in the formation of complex sugar structures (tri- and multiantennary) within the Golgi apparatus. It specifically adds N-acetylglucosamine (GlcNAc) to a specific arm of the sugar chain. This enzyme, along with its closely related counterpart MGAT4A, contributes to the production of tri- and tetra-antennary sugar chains. While important, MGAT4B has a lower affinity for its substrates compared to MGAT4A, suggesting it plays a less dominant role in overall N-glycan biosynthesis. Its function may be linked to regulating the levels of serum glycoproteins, influencing cell growth (oncogenesis), and cell differentiation.

MGAT4B is a glycosyltransferase that adds a GlcNAc sugar molecule to the core structure of N-linked glycans, specifically to the GlcNAcbeta1-2Manalpha1-3 arm, through a beta1-4 linkage. This enzyme plays a role in the synthesis of tri- and tetra-antennary N-linked sugar chains. MGAT4B prefers complex-type N-glycans over hybrid-types. It has a lower affinity for donor or acceptor molecules than its related enzyme MGAT4A, suggesting that it is not the main contributor to N-glycan biosynthesis under normal conditions. {ECO:0000269|PubMed:10372966, ECO:0000269|PubMed:17006639}

MGAT4B is also known as GNT-IV, GNT-IVB.

Associated Diseases

WES Whole Exome Sequencing