MGAT1

Description

The MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase) is a protein-coding gene located on chromosome 5.

MGAT1, the gene responsible for producing alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, is one of over 100 glycosyltransferases involved in the synthesis of oligosaccharides linked to proteins and lipids. This enzyme, located in the medial-Golgi, is crucial for creating hybrid and complex N-glycans. The protein encoded by MGAT1, which consists of a single exon, exhibits the characteristics of a type II transmembrane protein. MGAT1 is believed to be essential for normal embryonic development.

MGAT1 is also known as GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, GnTI, MGAT.

Associated Diseases

• COVID-19
• multiple sclerosis
• lysosomal storage disease
• Alzheimer disease
• Parkinson disease
• type 2 diabetes mellitus
• hemoglobin D disease
• overhydrated hereditary stomatocytosis
• IRIDA syndrome
• Rh deficiency syndrome
• X-linked dyserythropoetic anemia with abnormal platelets and neutropenia