MGA
Description
The MGA (MAX dimerization protein MGA) is a protein-coding gene located on chromosome 15.
MGA, a human gene, is associated with various fields, including biology, transportation, finance, geography, information technology, education, and art. In biology, MGA refers to the protein encoded by the MGA gene, which functions as a dual-specificity transcription factor. In transportation, MGA represents the IATA code for Augusto C. Sandino International Airport in Managua, Nicaragua. It also stands for the MG MGA, a British sports car. MGA is also used in finance, representing the currency of Madagascar, a type of insurance agent, and a negotiation process model. In geography, MGA refers to a mapping system and a river in Russia. The acronym also features in information technology, representing a video card component, a graphics card, and a method for handling database transactions. In education, MGA stands for Master of Governmental Administration and Master of Global Affairs. Finally, in art, MGA represents the Monash Gallery of Art in Melbourne, Australia.
MGA acts as a dual-specificity transcription factor, controlling the expression of genes within both the MAX network and T-box family. It can function as either a repressor or an activator. MGA binds to the 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence, likely regulating MYC-MAX target genes. It inhibits the activation of transcription by MYC and prevents MYC-dependent cell transformation. MGA's function is activated through heterodimerization with MAX. This interaction serves a dual purpose: it creates an E-box-binding heterodimer while also blocking the interaction of a corepressor.
MGA is also known as MAD5, MXD5.
