METTL12

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Title: Mettl12: An RNA Modifier with Far-Reaching Implications

Description:

Metallo-beta-lactamase domain containing 12 (mettl12), also known as the cap-1 methyltransferase, is an enzyme that plays a crucial role in regulating gene expression. It modifies the cap structure of eukaryotic messenger RNA (mRNA), adding a methyl group to the 1st nucleotide to form m7G. This modification stabilizes mRNA, promotes its translation, and affects its lifespan and stability.

Associated Diseases:

Alterations in mettl12 function have been linked to several diseases, including:

• Cancer: Mettl12 is overexpressed in many cancer types, promoting cell proliferation, invasion, and metastasis.
• Neurological disorders: Mutations in the mettl12 gene can lead to neurological disorders such as intellectual disability, autism spectrum disorder, and microcephaly.
• Metabolic disorders: Mettl12 plays a role in regulating glucose metabolism and has been implicated in conditions such as diabetes and obesity.

Did you Know ?

• Studies have shown that approximately 30% of cancer cells exhibit abnormal levels of mettl12 expression.