MEP1A
Description
The MEP1A (meprin A subunit alpha) is a protein-coding gene located on chromosome 6.
Meprin A subunit alpha, also known as endopeptidase-2 or PABA peptide hydrolase, is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice. The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons.
Meprin A is a metalloprotease that is involved in a variety of physiological processes, including extracellular matrix remodeling, cell adhesion, and inflammation. It is secreted as a homomeric protein, but can also form heteromeric complexes with other proteins. Meprin A is thought to play a role in the pathogenesis of a number of diseases, including cancer and arthritis.
MEP1A is also known as PPHA.
Associated Diseases
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- achalasia-alacrima syndrome
- cancer
- autosomal recessive polycystic kidney disease
- COVID-19
