MED29
Mast Cell Activation Syndrome (MCAS): A Comprehensive Guide
Description
Mast cell activation syndrome (MCAS) is a chronic condition characterized by the inappropriate activation of mast cells, leading to the release of a variety of inflammatory mediators. Mast cells are found throughout the body, including the skin, gastrointestinal tract, and respiratory system. When activated, they release histamine, tryptase, cytokines, and other mediators that can cause a wide range of symptoms.
Associated Diseases
MCAS has been associated with several other medical conditions, including:
- Anaphylaxis
- Asthma
- Chronic fatigue syndrome
- Ehlers-Danlos syndrome
- Gastrointestinal disorders (e.g., irritable bowel syndrome, gastroesophageal reflux disease)
- Joint pain and stiffness
- Skin rashes (e.g., urticaria, angioedema)
Did you Know ?
Approximately 1 in 500 individuals are estimated to have MCAS. However, it is often underdiagnosed due to its similarity to other medical conditions.
