MED22
Description
The MED22 (mediator complex subunit 22) is a protein-coding gene located on chromosome 9.
MED22, encoded by the MED22 gene in humans, is an enzyme involved in RNA polymerase II transcription. This gene is part of the 'surfeit gene cluster,' characterized by tightly linked housekeeping genes without sequence similarity. It's located in a head-to-head arrangement with RPL7A (SURF3), sharing a bidirectional promoter. The proteins produced from this gene reside in the cytoplasm. Two alternative transcript variants have been identified, resulting in different isoforms. MED22 has been found to interact with MED30.
MED22 is part of the Mediator complex, a vital coactivator for RNA polymerase II-dependent gene transcription. It acts as a bridge, transferring information from specific regulatory proteins to the core RNA polymerase II transcription machinery. Mediator binds to promoters through interactions with regulatory proteins, building a functional preinitiation complex alongside RNA polymerase II and essential transcription factors.
MED22 is also known as MED24, SRB6, SURF5, surf-5.
