MED19
Description
The MED19 (mediator complex subunit 19) is a protein-coding gene located on chromosome 11.
Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene. The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene.
MED19, also known as Lung cancer metastasis-related protein 1, is a crucial component of the Mediator complex. This complex acts as a coactivator, playing a vital role in regulating the transcription of almost all genes that rely on RNA polymerase II. Mediator functions as a bridge, relaying information from specific gene regulators to the core RNA polymerase II transcription machinery. It is recruited to gene promoters through direct interactions with regulatory proteins, serving as a scaffold to assemble a functional preinitiation complex with RNA polymerase II and essential transcription factors.
MED19 is also known as DT2P1G7, LCMR1, MED19AS.
