MED18
Description
The MED18 (mediator complex subunit 18) is a protein-coding gene located on chromosome 1.
MED18, or Mediator complex subunit 18, is a protein encoded by the MED18 gene in humans. It is part of the Mediator complex, a coactivator that facilitates the activation of transcription via RNA polymerase II by DNA-binding factors.
MED18, also known as Mediator complex subunit 18, is a crucial component of the Mediator complex. This complex acts as a coactivator, playing a vital role in regulating the transcription of nearly all genes that rely on RNA polymerase II. Essentially, Mediator acts as a bridge, relaying information from gene-specific regulatory proteins to the core machinery of RNA polymerase II transcription. This communication is initiated by Mediator's direct interaction with regulatory proteins at promoters, leading to the assembly of a functional preinitiation complex. This complex brings together RNA polymerase II and the general transcription factors, setting the stage for the initiation of transcription.
MED18 is also known as SRB5, p28b.
Associated Diseases
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9
- Miyoshi myopathy
- fungal infectious disease
- cancer
