MED16
Description
The MED16 (mediator complex subunit 16) is a protein-coding gene located on chromosome 19.
Mediator of RNA polymerase II transcription subunit 16 is an enzyme encoded by the MED16 gene in humans. MED16 interacts with Thyroid hormone receptor alpha, Estrogen receptor alpha, and Cyclin-dependent kinase 8.
MED16 is a component of the Mediator complex, a coactivator essential for the regulated transcription of almost all RNA polymerase II-dependent genes. The Mediator complex acts as a bridge, relaying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. It is recruited to promoters through direct interactions with regulatory proteins and serves as a scaffold for the formation of a functional preinitiation complex alongside RNA polymerase II and general transcription factors.
MED16 is also known as DRIP92, THRAP5, TRAP95.
