MED13
Description
The MED13 (mediator complex subunit 13) is a protein-coding gene located on chromosome 17.
MED13, encoded by the MED13 gene, is a protein that forms part of the Mediator complex, a crucial transcriptional coactivator involved in the expression of nearly all genes. The Mediator complex is recruited by transcriptional activators or nuclear receptors to initiate gene expression, possibly through interactions with RNA polymerase II and the promotion of a transcriptional pre-initiation complex formation. MED13 is believed to form a sub-complex with MED12, cyclin C, and CDK8, which can negatively regulate transactivation mediated by the Mediator complex.
MED13 is a component of the Mediator complex, a key coactivator that plays a crucial role in regulating the transcription of almost all genes that rely on RNA polymerase II. Acting as a bridge, Mediator facilitates communication between gene-specific regulatory proteins and the core RNA polymerase II transcription machinery. This process involves the recruitment of Mediator to promoters through direct interactions with regulatory proteins, where it serves as a scaffolding element for the assembly of a functional preinitiation complex alongside RNA polymerase II and general transcription factors.
MED13 is also known as ARC250, DRIP250, HSPC221, MRD61, THRAP1, TRAP240.
