MED10

---

Description

The MED10 (mediator complex subunit 10) is a protein-coding gene located on chromosome 5.

MED10 is a protein encoded by the MED10 gene in humans. It is a component of the Mediator complex, a coactivator that helps activate transcription via RNA polymerase II.

MED10 is a component of the Mediator complex, a crucial coactivator that regulates transcription of almost all genes dependent on RNA polymerase II. It acts as a bridge, transmitting information from specific regulatory proteins to the basic RNA polymerase II transcription machinery. Mediator attaches to promoters through direct interactions with regulatory proteins and serves as a framework for building a functional preinitiation complex with RNA polymerase II and essential transcription factors.

MED10 is also known as L6, NUT2, TRG20.

Associated Diseases

• hemoglobin D disease
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
• hemoglobin E disease
• dominant beta-thalassemia
• hemoglobin E-beta-thalassemia syndrome
• delta-beta-thalassemia
• thrombocytopenia, anemia, and myelofibrosis
• alpha-thalassemia-myelodysplastic syndrome
• primary familial polycythemia due to EPO receptor mutation
• hemoglobin C-beta-thalassemia syndrome
• ghosal hematodiaphyseal dysplasia
• hemoglobin H disease
• bone marrow failure syndrome 6
• monosomy 7 myelodysplasia and leukemia syndrome 1
• beta-thalassemia-X-linked thrombocytopenia syndrome