MDS2
The MDS2 gene (Myelodysplastic Syndrome 2 Translocation Associated) is a long non-coding RNA (lncRNA) gene located on chromosome 8 in humans. lncRNAs are RNA molecules that do not code for proteins but play important roles in regulating gene expression. While the precise function of the MDS2 gene is not fully understood, it has been implicated in the development of certain diseases, particularly myelodysplastic syndromes (MDS).
Associated Diseases:
- Myelodysplastic Syndromes (MDS): MDS are a group of blood cancers characterized by ineffective blood cell production in the bone marrow. This can lead to low levels of red blood cells, white blood cells, and platelets, causing various symptoms such as fatigue, infections, and bleeding. The MDS2 gene is often involved in chromosomal translocations (rearrangements) that occur in some types of MDS, suggesting a role in the development of these disorders.
- Acute myeloid leukemia (AML): About 30-40% of MDS patients progress to AML.
- Paroxysmal nocturnal hemoglobinuria (PNH): A rare, life-threatening blood disorder that affects red blood cells, white blood cells, and platelets.
- Aplastic anemia: A condition characterized by a severe reduction in all blood cell lineages.
- Multiple myeloma: A cancer that affects plasma cells, which produce antibodies.
Did you Know ?
In the United States, approximately 10,000 new cases of MDS are diagnosed each year. The median age at diagnosis is 70 years, and the incidence increases with age.
