MCMDC2
Description
The MCMDC2 (minichromosome maintenance domain containing 2) is a protein-coding gene located on chromosome 8.
MCMDC2 is crucial for meiotic recombination, a process that shuffles genetic material during the formation of sperm and egg cells, and for repairing double-strand breaks in DNA, which are common during this process.
MCMDC2 is also known as C8orf45.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 74
- spermatogenic failure 73
- congenital bilateral absence of vas deferens
- spermatogenic failure 61
- spermatogenic failure 48
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
- isochromosomy Yp
- spinocerebellar ataxia type 32
- spermatogenic failure 22
- spermatogenic failure 65
- spermatogenic failure, X-linked, 3
- isochromosomy Yq
- spermatogenic failure 70
- spermatogenic failure 40
- spermatogenic failure 52
- spermatogenic failure 23
