MCM7
Description
The MCM7 (minichromosome maintenance complex component 7) is a protein-coding gene located on chromosome 7.
MCM7 is a protein involved in DNA replication. It is part of a complex called MCM2-7, which is essential for initiating DNA replication in eukaryotic cells. The complex acts as a helicase, unwinding DNA strands during replication. MCM7 is also involved in the formation of replication forks, structures where DNA replication takes place. It interacts with other proteins involved in DNA replication, like the tumor suppressor RB1/RB, and is regulated by cyclin D1-dependent kinase (CDK4). There are different forms of the MCM7 protein, produced from alternative splicing of the MCM7 gene.
MCM7 is a crucial component of the MCM2-7 complex, a replicative helicase essential for DNA replication initiation and elongation once per cell cycle in eukaryotes. It is a core component of the CMG helicase, which unwinds DNA during replication. The CMG helicase also acts as a scaffold for the replisome, a complex of proteins that carries out DNA replication. MCM7's role in the MCM2-7 ring involves ATPase activity, which is facilitated by interactions between neighboring subunits. This activity is essential for the helicase function. Additionally, MCM7 is involved in activating the S-phase checkpoint in response to UV damage.
MCM7 is also known as CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104.
