MCM6
Description
MCM6, or Minichromosome Maintenance Complex Component 6, is an essential protein that plays a critical role in DNA replication. It‘s a subunit of the MCM complex, a hexameric ring-shaped structure that acts as a DNA helicase. This complex unwinds the double helix of DNA, allowing for the synthesis of new DNA strands during cell division. MCM6‘s function is crucial for maintaining genomic integrity and preventing errors in DNA replication. Dysfunction in MCM6 can lead to various cellular problems and diseases.
Associated Diseases
- Cancer: Mutations in MCM6 have been linked to an increased risk of various cancers, including breast, ovarian, and colorectal cancers.
- Developmental disorders: Defects in MCM6 can contribute to developmental abnormalities, potentially affecting organ development and growth.
- Infertility: MCM6 dysfunction can impact fertility due to its role in DNA replication during germ cell development.
- Neurological disorders: Studies suggest a potential link between MCM6 dysfunction and neurological disorders, although more research is needed.
Did you know?
The MCM complex, including MCM6, is highly conserved across many organisms, indicating its fundamental importance in DNA replication.
