MCM3
Description
The MCM3 (minichromosome maintenance complex component 3) is a protein-coding gene located on chromosome 6.
MCM3 is a protein that plays a key role in DNA replication initiation in eukaryotic cells. It is part of the MCM2-7 complex, which is a hexameric protein complex essential for the initiation of eukaryotic genome replication. The MCM2-7 complex is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and the recruitment of other DNA replication-related proteins. MCM3 interacts directly with MCM5/CDC46 and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. Acetylation of MCM3 inhibits the initiation of DNA replication and cell cycle progression.
MCM3 is a component of the MCM2-7 complex, which is a replicative helicase essential for initiating and elongating DNA replication once per cell cycle in eukaryotic cells. It is a core component of the CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through interactions between neighboring subunits, with a conserved arginine finger motif provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. While the six ATPase active sites likely contribute differentially to the complex helicase activity, MCM3 is required for entry into S phase and for cell division.
MCM3 is also known as HCC5, P1-MCM3, P1.h, RLFB.
Associated Diseases
- ovarian cancer
- esophageal cancer
- Meier-Gorlin syndrome
- urinary bladder cancer
- cancer
- Mobius syndrome
- hemoglobin D disease
- alpha thalassemia-intellectual disability syndrome type 1
- retinoblastoma
- dominant beta-thalassemia
- hemoglobin E disease
