MCL1
Description
The MCL1 (MCL1 apoptosis regulator, BCL2 family member) is a protein-coding gene located on chromosome 1.
MCL1 is a protein encoded by the MCL1 gene in humans. It belongs to the Bcl-2 family and plays a crucial role in regulating apoptosis (programmed cell death). Two isoforms of MCL1 are produced through alternative splicing: Isoform 1 promotes cell survival by inhibiting apoptosis, while Isoform 2 promotes apoptosis. MCL1 has a short half-life of only 20-30 minutes. Its loss has a significant impact on various cell types, including hematopoietic stem cells, B and T cell progenitors, plasma cells, cardiac muscle cells, and neurons. The loss of MCL1 in embryos results in death around 3.5 days old. In hepatocytes, MCL1 deletion causes apoptosis and polyploidy, but it can improve liver regeneration after surgery. MCL1 works synergistically with p53 to protect the liver from injury, fibrosis, and cancer.
MCL1 is also known as BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT.
