MBD3
Description
The MBD3 (methyl-CpG binding domain protein 3) is a protein-coding gene located on chromosome 19.
Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to hydroxymethylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. MBD3 also contains the coiled‐coil domain common to all three MBD3 isoforms. MBD3 has been shown to interact with: AURKA, GATAD2B, HDAC1, MTA2, and MBD2.
MBD3 is a component of the histone deacetylase NuRD complex, which is involved in chromatin remodeling. It acts as a transcriptional repressor and contributes to gene silencing. Although it does not directly bind to methylated DNA, it can bind to DNA containing unmethylated CpG dinucleotides. MBD3 plays a role in recruiting histone deacetylases and DNA methyltransferases.
MBD3 is also known as -.
