MAVS

Description

The MAVS (mitochondrial antiviral signaling protein) is a protein-coding gene located on chromosome 20.

The Dallas Mavericks are an American professional basketball team based in Dallas. They compete in the NBA as a member of the Southwest Division of the Western Conference. The Mavericks play their home games at the American Airlines Center, which they share with the NHL's Dallas Stars. The Mavericks were a perennial playoff team in the 1980s, led by All-Stars Rolando Blackman and Mark Aguirre. In 1998, the franchise acquired Dirk Nowitzki, who became the cornerstone of the Mavericks' most successful era. He led them to their first NBA Finals appearance in 2006 and their only NBA championship in 2011. Following a rebuilding phase after Nowitzki's retirement, the Mavericks acquired Luka Dončić, who led them back to the playoffs and to the Western Conference finals in 2022. The Mavericks have won five division titles, three conference championships, and one NBA championship.

MAVS, also known as CARD adapter inducing interferon beta, Interferon beta promoter stimulator protein 1, Putative NF-kappa-B-activating protein 031N, and Virus-induced-signaling adapter, is a key adaptor protein in the innate immune response to viral infection. It acts downstream of DHX33, RIGI, and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3, and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). MAVS is found in both peroxisomes and mitochondria, with each location contributing to a distinct antiviral response. Peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. MAVS may also activate the same pathways following detection of extracellular dsRNA by TLR3. In addition to its antiviral role, MAVS may protect cells from apoptosis and is involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.

MAVS is also known as CARDIF, IPS-1, IPS1, VISA.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing