MASTL

Description

The MASTL (microtubule associated serine/threonine kinase like) is a protein-coding gene located on chromosome 10.

MASTL is a human gene with the official symbol MASTL, representing micro tubule associated serine/threonine kinase like. This gene is located on chromosome 10 and is approximately 32.1 kbps in length. It is also known by various aliases including GW, GWL, THC2, MAST-L, and GREATWALL. MASTL is primarily found in mammalian cells such as humans, mice, cattle, and monkeys. The protein encoded by MASTL is a micro tubule associated serine/threonine kinase, a mammalian enzyme initially discovered in Drosophila as an essential kinase (Greatwall) for proper chromosome condensation and mitotic progression. This enzyme is classified with the EC number 2.7.11.12 and plays a critical role in mitotic division. It is localized primarily in the nucleus during interphase and disperses into the cytoplasm upon the degradation of the nuclear envelope during mitosis. Recent research has extended studies to include zebrafish and frogs.

MASTL is a serine/threonine kinase that plays a crucial role in the M phase of the cell cycle by regulating the entry and maintenance of mitosis. It achieves this by promoting the inactivation of protein phosphatase 2A (PP2A) during the M phase. Notably, MASTL does not directly inhibit PP2A but instead acts by mediating the phosphorylation and subsequent activation of ARPP19 and ENSA at Ser-62 and Ser-67, respectively. ARPP19 and ENSA are known phosphatase inhibitors that specifically target the PPP2R2D (PR55-delta) subunit of PP2A. The inactivation of PP2A during the M phase is essential to maintain high cyclin-B1-CDK1 activity. Following DNA damage, MASTL is also involved in checkpoint recovery through its inhibition. MASTL has been shown to phosphorylate histone proteins in vitro, although the significance of this activity in vivo remains unclear. Additionally, MASTL may play a role in megakaryocyte differentiation.

MASTL is also known as GREATWALL, GW, GWL, MAST-L, THC2.

Associated Diseases

• multiple sclerosis
• Parkinson disease
• lysosomal storage disease
• Alzheimer disease
• endometrial cancer
• thrombocytopenia 2
• scimitar anomaly, multiple cardiac malformations, and craniofacial and central nervous system abnormalities
• cancer