MARK1
Description
The MARK1 (microtubule affinity regulating kinase 1) is a protein-coding gene located on chromosome 1.
MARK1, also known as MAP/microtubule affinity-regulating kinase 1, or PAR1 homolog c, is an enzyme that in humans is encoded by the MARK1 gene. It is a serine/threonine-protein kinase (PubMed:23666762).
Serine/threonine-protein kinase (PubMed:23666762). Plays a role in regulating cell polarity and microtubule dynamics. It phosphorylates proteins such as DCX, MAP2, and MAP4, including the microtubule-associated protein MAPT/TAU (PubMed:23666762). This phosphorylation at KXGS motifs on MAP2, MAP4, and MAPT/TAU leads to their detachment from microtubules and subsequent disassembly, contributing to cell polarity. It also influences neuronal migration by regulating cellular polarity and microtubule dynamics, potentially through the phosphorylation and regulation of DCX. Moreover, it acts as a positive regulator of the Wnt signaling pathway, possibly by phosphorylating dishevelled proteins (DVL1, DVL2, and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}
MARK1 is also known as MARK, Par-1c, Par1c.
